When my son and his family made the long journey from Honolulu to North Carolina, I couldn’t help but reflect on the concept of “Dayenu” that he brought up during our conversation. The idea that each step along the way is significant and worthy of gratitude can have a profound impact in the field of
Health
The disruption of circadian rhythms in cognitively normal adults has been linked to higher levels of amyloid-beta, according to recent findings in a prospective study. The study, conducted by researchers at Erasmus University Medical Center in Rotterdam, the Netherlands, found that higher daily variability at baseline correlated with increased PET amyloid burden 8 years later.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a rare and debilitating immune-mediated neuromuscular disorder of the peripheral nervous system. Patients suffering from CIDP have limited treatment options, usually consisting of corticosteroids and plasma-derived therapies. However, a new treatment option has emerged with the FDA’s recent decision to expand the indication of efgartigimod alfa and hyaluronidase-qvfc (Vyvgart
The LENS trial, as discussed and presented at the American Diabetes Association annual meeting, showcased some promising results regarding the use of fenofibrate in reducing the progression of early eye disease among diabetes patients. The findings revealed a relative 27% decrease in the progression of early diabetic retinopathy or maculopathy over a span of 4
The drug sample in question contained a mix of nitazenes, fentanyl analogues, xylazine, diphenhydramine, caffeine, and medetomidine. While familiar with managing overdoses, the mentioned specimen stood out due to its unusual effects. The patient presented like a classic opioid overdose, but standard treatments were ineffective. The discovery of medetomidine in the sample shed light on
Recent developments in the treatment of EGFR-mutated non-small cell lung cancer have brought about exciting new data regarding the use of osimertinib (Tagrisso). Dr. Roy Herbst of Yale Cancer Center has shed light on the significant improvements in progression-free survival (PFS) seen in patients with advanced disease. The findings from both the LAURA and ADAURA
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs in the body, including the kidneys. A recent analysis of medical records suggested that individuals with SLE who were taking metformin had lower rates of lupus nephritis, chronic kidney disease (CKD), and major adverse cardiovascular events (MACE) compared to those not
Patients with rheumatoid arthritis (RA) can greatly benefit from regular high-sensitivity cardiac troponin T (hs-cTnT) testing, according to researchers. In a study conducted at Brigham and Women’s Hospital in Boston, RA patients who tested positive for hs-cTnT were found to have a significantly increased risk of major adverse cardiovascular events (MACE) and all-cause mortality, even
A recent study sheds light on the missed opportunities in treating drug overdose survivors covered by the Medicare program. The study highlights the complexities involved in managing chronic pain and addiction. According to the findings published in JAMA Internal Medicine, overdose survivors on Medicare in 2020 were disproportionately prescribed opioid painkillers rather than receiving proper
In a recent announcement by the FDA, two new immunotherapy-chemotherapy options have been approved for patients with primary advanced or recurrent endometrial cancer. This approval opens up new possibilities for treatment for individuals with both mismatch repair (MMR)-deficient and MMR-proficient disease. The first immunotherapy option approved is the PD-1-directed immune checkpoint inhibitor pembrolizumab, in combination